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Case #1
1/30
Datos demográficos: 38 años, Masculino
Indicación: Seizure

Case #1

Hallazgos

  • T1 hypointense, T2 hyperintense expansile mass extending to the cortex in the left superior frontal gyrus
  • Mixed hyperintense and isointense internal FLAIR signal
  • No corresponding enhancement, restricted diffusion, or susceptibility artifact
  • Mild corresponding local mass effect without midline shift or evidence of herniation or hydrocephalus

Imágenes anotadas e ilustraciones

The T2-FLAIR mismatch sign: the lesion demonstrates internal T2 signal hyperintensity (red arrow) contrasted to relatively hypointense FLAIR signal (yellow arrow).

The T2-FLAIR mismatch sign: the lesion demonstrates internal T2 signal hyperintensity (red arrow) contrasted to relatively hypointense FLAIR signal (yellow arrow).

Diagnóstico

IDH-mutant astrocytoma

Diagnóstico diferencial

  • Dysembryoplastic neuroepithelial tumor (DNET) - This case is actually a very good look for a DNET, specifically bubbly internal T2 signal hyperintensity, signal suppression on FLAIR, and lack of contrast enhancement. DNETs are often smaller than the tumor in this case
  • Ganglioglioma - These tumors are also often peripheral, but commonly enhance and have associated calcification. These tumors more frequently involve the temporal lobes
  • Oligodendroglioma - These tumors may also be peripheral, they commonly calcify, and they sometimes enhance. The T2-FLAIR mismatch sign (hyperintense T2 signal contrasted with iso- or hypointense FLAIR signal) is typical for 1p19q intact astrocytomas, but NOT typical for oligodendrogliomas

Puntos clave

  • Any peripheral tumor can present with seizures
  • The T2-FLAIR mismatch sign can be seen with both astrocytomas and DNETs, but is not typical for oligodendrogliomas

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